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Responding double-porous lipid membrane: Lyotropic phases in a polymer scaffold
Åberg, Christoffer; Pairin, Cécile; Costa-Balogh, Fátima O.; Sparr, EmmaThe large osmotic gradient over the outermost layer of human skin implies major structural changes along the gradient, which in turn affects transport. In particular, the possibility of phase changes introduces a non-linear element to the transport behaviour. We present a novel model membrane system to be used for studying these transport mechanisms, where we use a hydrophobic porous polymer membrane as a scaff...
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Os...
Costa-Balogh, Fátima O.; Åberg, Christoffer; Sousa, João J. S.; Sparr, EmmaIn this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear tr...
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