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Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to n...
Santos-Carvalho, Ana; Álvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, CláudiaNeuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the d...
O neuropeptídeo Y e os seus receptores na retina : da proliferação celular à ne...
Álvaro, Ana Rita Costa SilvaO neuropeptídeo Y (NPY) é o peptídeo mais abundante no sistema nervoso central e periférico, e está também presente na retina. Porém, a função do NPY na retina está ainda por esclarecer. Com esta tese, pretendeu-se aumentar o estado actual do conhecimento sobre as funções que o NPY pode desempenhar na retina. Neste estudo começou-se por caracterizar a expressão do NPY nas células da retina, tendo-se utilizado d...
NPY in rat retina is present in neurons, in endothelial cells and also in micro...
Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; Gouveia, DenisaNPY is present in the retina of different species but its role is not elucidated yet. In this work, using different rat retina in vitro models (whole retina, retinal cells in culture, microglial cell cultures, rat Müller cell line and retina endothelial cell line), we demonstrated that NPY staining is present in the retina in different cell types: neurons, macroglial, microglial and endothelial cells. Retinal c...
Intracellular signaling mechanisms mediating catecholamine release upon activat...
Rosmaninho-Salgado, Joana; Araújo, Inês M.; Álvaro, Ana Rita; Duarte, Emília P.; Cavadas, CláudiaThe adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release f...
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