Calcineurin inhibitor-free immunosuppression in renal transplantation

• Author(s): Parada, B ; Mota, A ; Nunes, P ; Macário, F ; Pratas, J ; Bastos, C ; Figueiredo, A
• Date: 2005
• Persistent ID: http://hdl.handle.net/10400.4/1055
• Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
• Subject(s): Insuficiência Renal Crónica; Transplantação de Rim; Calcineurina; Imunossupressores
• Document Type: Article
• Language: English

Description

PURPOSE: To describe our initial results using a calcineurin inhibitor-free immunosuppression protocol in renal transplants. PATIENTS AND METHODS: Between October 2001 and June 2003, 56 recipients of a renal allografts were started on an immunosuppression protocol without calcineurin inhibitors, consisting of basiliximab, sirolimus, mycophenolate mofetil, and steroids. We analyzed patient and graft survival, acute rejection episodes, and renal function. RESULTS: The mean follow-up was 19.6 months. Actuarial patient survival at 1 and 2 years was 98.1% and 95.3%, respectively. Actuarial graft survival at 1 and 2 years was 92.9% and 87.6%, respectively. Acute rejection occurred in 27.8% of the patients, usually Banff 1 (73.3%). There was stable renal function with mean serum creatinine of 1.3, 1.4, 1.3, and 1.3 mg/dL at 1, 6, 12, and 24 months after transplant. CONCLUSIONS: The use of immunosuppression free of calcineurin inhibitors is effective and safe. Further follow-up is needed to evaluate the impact on long-term results.