Synthesis and photophysical characterization of new fluorescent bis-amino acid...

• Author(s): Costa, Susana P. G. ; Batista, Rosa M. F. ; Raposo, M. Manuela M.
• Date: 2008
• Persistent ID: http://hdl.handle.net/1822/8094
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Bis-amino acids; (Oligo)thiophene; Formyl-(oligo)thiophenes; Benzoxazole; Fluorescence; Fluorescent probes; Bis-alanines
• Document Type: Article
• Language: English

Description

A series of new bis-alanine derivatives bearing (oligo)thiophene and benzoxazole units as the heteroaromatic bridge were synthesized in moderate to good yields. The photophysical characterization of these bis-amino acids was performed by UV-visible absorption and fluorescence emission studies and revealed that the compounds displayed exceptionally high fluorescence quantum yields, making them good candidates for application as fluorescent probes when incorporated into peptides, as well as peptide conformationrestricting and cross-linking elements.