Antifungal activity of a novel chromene dimer

• Author(s): Abrunhosa, Luís ; Costa, M. ; Areias, F. ; Venâncio, Armando ; Proença, M. Fernanda R. P.
• Date: 2007
• Persistent ID: http://hdl.handle.net/1822/7467
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Chromenes; Aspergillus spp.; Ochratoxin A; Antifungal compounds
• Document Type: Article
• Language: English

Description

The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC50) at 140.1 μmol L−1 for A. niger, 384.2 μmol L−1 for A. carbonarius, 69.1 μmol L−1 for A. alliaceus and 559.1 μmol L−1 for A. ochraceus. When applied at concentrations of 2 mmol L−1, 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 μmol L−1 solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3.