Identification of yield coefficients in an E. coli model : an optimal experimen...

• Author(s): Veloso, Ana C. A. ; Rocha, I. ; Ferreira, E. C.
• Date: 2005
• Persistent ID: http://hdl.handle.net/1822/2880
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Optimisation; Genetic algorithms; Fisher information matrix; Fed-batch fermentation; E. coli; Yield coefficients
• Document Type: Conference Object
• Language: English

Description

An optimal experimental design for yield coefficients estimation in an unstructured growth model of fed-batch fermentation of E. coli is presented. The feed profile is designed by optimisation of a scalar function based on the Fischer Information Matrix. A genetic algorithm is proposed as the optimisation method due to its efficiency and independence on the initial values.