Identification of yield coefficients in an E. coli model : an optimal experimen...

• Autor(es): Veloso, Ana C. A. ; Rocha, I. ; Ferreira, E. C.
• Data: 2005
• Identificador Persistente: http://hdl.handle.net/1822/2880
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Optimisation; Genetic algorithms; Fisher information matrix; Fed-batch fermentation; E. coli; Yield coefficients
• Tipo de Documento: Documento de conferência
• Idioma: Inglês

Descrição

An optimal experimental design for yield coefficients estimation in an unstructured growth model of fed-batch fermentation of E. coli is presented. The feed profile is designed by optimisation of a scalar function based on the Fischer Information Matrix. A genetic algorithm is proposed as the optimisation method due to its efficiency and independence on the initial values.