Physical-chemical properties of cross-linked chitosan electrospun fiber mats

• Autor(es): Sencadas, V. ; Correia, D. M. ; Ribeiro, C. ; Moreira, Susana ; Botelho, Gabriela ; Gómez Ribelles, J. L. ; Lanceros-Méndez, S.
• Data: 2012
• Identificador Persistente: http://hdl.handle.net/1822/23211
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Chitosan scaffolds; Electrospinning; Crystallinity; Biomaterials; Nanofibers
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 ± 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61 % for the Protasan material down to 17 % for the cross-linking fiber mats. A swelling index up to 1000 % was observed for the cross-linked samples. Preliminary MC-3T3-E1cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats.