Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo...

• Autor(es): Ferreira, Isabel C. F. R. ; Calhelha, Ricardo C. ; Estevinho, Letícia M. ; Queiroz, Maria João R. P.
• Data: 2004
• Identificador Persistente: http://hdl.handle.net/1822/2239
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Diarylamines; Antimicrobial activity; SAR; Benzothiophenes
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Gram positive (Bacillus cereus, Bacillus subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethyl benzo[b]thiophene series bearing different substituents, synthesised by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.