Synthesis of novel derivatives of a versatile synthon : 4-amino-3-cyanopyrazole

• Author(s): Rodrigues, Lígia M. ; Campos, Ana M. F. Oliveira ; Kaja, Martin ; Hrdina, Radim
• Date: 2004
• Persistent ID: http://hdl.handle.net/1822/1971
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Cyanopyrazole; Oxo-pyrazolopyrimidine; Pyrazole
• Document Type: Conference Object
• Language: English

Description

Diazotisation of substituted arylamines followed by reaction with malononitrile gave substituted arylazomalononitriles. Cyclisation of these intermediates with two carbon sources and base gave the corresponding new 4-amino-3-cyanopyrazoles, in moderate yields. In one case the corresponding oxo-pyrazolopyrimidine was prepared.