Synthesis of novel derivatives of a versatile synthon : 4-amino-3-cyanopyrazole

• Autor(es): Rodrigues, Lígia M. ; Campos, Ana M. F. Oliveira ; Kaja, Martin ; Hrdina, Radim
• Data: 2004
• Identificador Persistente: http://hdl.handle.net/1822/1971
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Cyanopyrazole; Oxo-pyrazolopyrimidine; Pyrazole
• Tipo de Documento: Documento de conferência
• Idioma: Inglês

Descrição

Diazotisation of substituted arylamines followed by reaction with malononitrile gave substituted arylazomalononitriles. Cyclisation of these intermediates with two carbon sources and base gave the corresponding new 4-amino-3-cyanopyrazoles, in moderate yields. In one case the corresponding oxo-pyrazolopyrimidine was prepared.