A whole genome screen for association with multiple sclerosis in portuguese pat...

• Author(s): Santos, M. ; Pinto-Basto, J. ; Rio, M. E. ; Valença, Angela ; Sá, Alfredo ; Dinis, J. ; Figueiredo, J. ; Bigotte de Almeida, Luís ; Coelho, I. ; Sawcer, S. ; Setakis, E. ; Compston, A. ; Sequeiros, Jorge ; Maciel, P.
• Date: 2003
• Persistent ID: http://hdl.handle.net/1822/1646
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Genome screen; Linkage disequilibrium; Portugal; Multiple sclerosis; DNA pooling
• Document Type: Article
• Language: English

Description

Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n = 188) and matched controls (n = 188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.