Synthesis of tacrine analogues derived from n-aryl-5-amino-4-cyanopyrazoles

• Author(s): Rodrigues, Lígia M. ; Francisco, Carla Santana ; Campos, Ana M. F. Oliveira ; Salaheldin, Abdellatif M.
• Date: 2008
• Persistent ID: http://hdl.handle.net/1822/12596
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Alzheimer’s disease; Friedländer reaction; Aminocyanopyrazole,; Niitrogen heterocycles; Tacrine analogues,
• Document Type: Article
• Language: English

Description

Synthesis of eleven tacrine analogues derived from N-aryl-5-amino-4-cyanopyrazoles, by a Friedländer type reaction, is described. Their structures were confirmed by 1H and 13C NMR spectroscopy, elemental analysis and/or mass spectrometry.