Heterocyclic synthesis with nitriles : synthesis of pyrazolopyrimidine and pyra...

• Autor(es): Salaheldin, Abdellatif M. ; Campos, Ana M. F. Oliveira ; Rodrigues, Lígia M.
• Data: 2009
• Identificador Persistente: http://hdl.handle.net/1822/12593
• Origem: RepositóriUM - Universidade do Minho
• Assunto(s): Aminopyrazole; Pyrazolo[3,4-b]pyridines; Pyrazolo[3,4-d]pyrimidines; Diethylmalonate; Malononitrile
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

The reaction of N1-substituted-5-amino-4-cyanopyrazoles with malononitrile and diethylmalonate occurs with formation of 6-substituted pyrazolo[3,4-d]pyrimidines, and pyrazolo[3,4-b]pyridines respectively. The structures of the products and conceivable mechanisms are discussed.