Heterocyclic synthesis with nitriles : synthesis of pyridazine and pyridopyrida...

• Author(s): Campos, Ana M. F. Oliveira ; Salaheldin, Abdellatif M. ; Rodrigues, Lígia M.
• Date: 2007
• Persistent ID: http://hdl.handle.net/1822/10487
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Pyrido[3,2-c]pyridazine; Pyridazine; Malononitrile
• Document Type: Conference Object
• Language: English

Description

The reaction of MND with aryldiazonium chlorides followed by cyclization afforded the pyridazinimine derivatives. Reaction of the latter with another mole of malononitrile produce only pyrido[3,2-c]pyridazine derivatives. Reaction of 4-aminopyridazinone-3- carboxylic acid esters with malononitrile gave only pyridazine-3-carboxylic acid.