Author(s):
Paiva, Ana L. 
; Malcata, F. Xavier
Date: 1994
Persistent ID: http://hdl.handle.net/10400.14/6873
Origin: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Document details
Process integration involving lipase-catalyzed ester synthesis reactions
Description
The technical feasibility of integrating bioconversion (using a lipase from Mucor miehei immobilized by ion exchange onto a macroporous resin) and product recovery (via mass transfer towards liquid/vapor equilibrium) was experimentally verified for the production of ethyl acetate from acetic acid and ethanol at 30 and 40 °C. The configuration selected consisted of a packed bed thermostatted reactor inserted between the condenser and the liquid reflux to a distillation column. The concentrations of the aforementioned components and water were measured periodically for a 9 to 10-h period. The extents of conversion of acetic acid ranged from 1 to 32% at 30 °C, and from 13 to 25% at 40 °C, and they were maximum at initial molar fractions of acid of ca. 0.3 and 0.4, respectively. The ratio of the reaction product to the equilibrium reaction product increased from 2 to 32 at 30 °C, and from 5 to 27 at 40 °C when the initial molar fraction of acid in the feed increased from 0.2 to 0.7.
The technical feasibility of integrating bioconversion (using a lipase from Mucor miehei immobilized by ion exchange onto a macroporous resin) and product recovery (via mass transfer towards liquid/vapor equilibrium) was experimentally verified for the production of ethyl acetate from acetic acid and ethanol at 30 and 40 °C. The configuration selected consisted of a packed bed thermostatted reactor inserted between the condenser and the liquid reflux to a distillation column. The concentrations of the aforementioned components and water were measured periodically for a 9 to 10-h period. The extents of conversion of acetic acid ranged from 1 to 32% at 30 °C, and from 13 to 25% at 40 °C, and they were maximum at initial molar fractions of acid of ca. 0.3 and 0.4, respectively. The ratio of the reaction product to the equilibrium reaction product increased from 2 to 32 at 30 °C, and from 5 to 27 at 40 °C when the initial molar fraction of acid in the feed increased from 0.2 to 0.7.
Document Type
Article
Language English
Language English
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