Author(s):
Pinto, Diana C. G. A. 
; Seca, Ana M. L. ; Leal, Stephanie B. ; Silva, Artur M. S. ; Cavaleiro, José A. S.
Date: 2011
Persistent ID: http://hdl.handle.net/10400.3/2922
Origin: Repositório da Universidade dos Açores
Subject(s): Xanthenodiones; Synthesis
Description
23rd ISHC Congress will be held in Glasgow, Scotland from July 31 August 4, 2011. Chromones are a class of oxygen heterocyclic compounds widely distributed in Nature. 2-Styrylchromones are, however, a small and rare naturally occurring chromones; only three derivatives have been isolated, two from the marine blue green algae Chrysophaeum taylori1 and one from the rhizomes of Imperata cylindrical. Even so, 2-styrylchromone derivatives are associated with noticeable biological activities. Our group has also been interested in the synthesis and biological evaluation of 3-aroylflavones and found that 3’,4’,5,7-tetrahydroxy-3-(3,4-dihydroxybenzoyl)flavone is a potential antioxidant agent. As part of our continuing work on the synthesis and antioxidant evaluations of polyhydroxy-2-styrylchromones,4 we set up a program aiming the synthesis of 3-cinnamoyl-2-styrylchromone (2) bearing hydroxyl groups, features considered essential to be good antioxidant and anti-inflammatory agents.
