Document details

Biomarkers of exposure to metal dust in exhaled breath condensate: methodology ...

Author(s): Félix, P. M. cv logo 1 ; Franco, C. cv logo 2 ; Barreiros, Maria Alexandra cv logo 3 ; Batista, B. cv logo 4 ; Bernardes, S. cv logo 5 ; Garcia, S. M. cv logo 6 ; Almeida, A. B. cv logo 7 ; Almeida, S. M. cv logo 8 ; Wolterbeek, H. Th. cv logo 9 ; Pinheiro, Teresa cv logo 10

Date: 2013

Persistent ID: http://hdl.handle.net/10400.9/2415

Origin: Repositório do LNEG

Subject(s): Metal exposure; Biomonitoring; ICP-MS; Lead; TXRF


Description
In occupational assessments where workers are exposed to metal dust, the liquid condensate of exhaled breath (EBC) may provide unique indication of pulmonary exposure. The main goal of this study was to demonstrate the quality of EBC to biological monitoring of human exposure. A pilot study was performed in a group of metal dust–exposed workers and a group of nonexposed individuals working in offices. Only metal dust–exposed workers were followed along the working week to determine the best time of collection. Metal analyses were performed with inductively coupled plasma mass spectrometry (ICP-MS). Analytical methodology was tested using an EBC sample pool for several occupationally exposed metals: potassium, chromium, manganese, copper, zinc, strontium, cadmium, antimony, and lead. Metal contents in EBC of exposed workers were higher than controls at the beginning of the shift and remained augmented throughout the working week. The results obtained support the establishment of EBC as an indicator of pulmonary exposure to metals.
Document Type Article
Language English
delicious logo  facebook logo  linkedin logo  twitter logo 
degois logo
mendeley logo

Related documents



    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento EU