Analysis of the interference of endogenous circadian rhythms on 3'- deoxy- 3'- ...

• Author(s): Varela, N. M. ; Lucena, Filipa ; Carapinha, Maria João ; Vieira, Lina
• Date: 2011
• Persistent ID: http://hdl.handle.net/10400.21/2514
• Origin: Repositório Científico do Instituto Politécnico de Lisboa
• Subject(s): Nuclear medicine; Endogenous circadian rhythms; Human bone marrow; 18F-Fluorothymidine
• Document Type: Conference Object
• Language: English

Description

The main purpose of the present study is to determine if the circadian rhythms present in the human bone marrow are likely to influence 3’- deoxy- 3’-[18F] Fluorothymidine (18F-FLT) uptake in the same organ. The 18F-FLT is a Thymidine analogous proliferation agent. The relatively high physiological uptake of this tracer in the bone marrow diminishes the Tumor/Background (T/B) ratio, decreasing the detection accuracy of PET/CT and possibly affecting SUV quantifications.