Genome-wide linkage analyses of quantitative and categorical autism subphenotypes

• Author(s): Liu, X.Q. ; Paterson, A.D. ; Szatmari, P. ; Autism Genome Project Consortium
• Date: 2008
• Persistent ID: http://hdl.handle.net/10400.18/332
• Origin: Repositório Científico do Instituto Nacional de Saúde
• Subject(s): Autism; Genetic heterogeneity; IQ; Language; Linkage analysis; Schizophrenia; Perturbações do Desenvolvimento Infantil e Saúde Mental
• Document Type: Article
• Language: English

Description

Member of the Autism Genome Project Consortium: Astrid Moura Vicente The search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of autism since they may be more directly related to the underlying susceptibility loci. Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity.