Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase...

• Author(s): Manso, H. ; Krug, T. ; Sobral, J. ; Albergaria, I. ; Gaspar, G. ; Ferro, J.M. ; Oliveira, S.A. ; Vicente, AM.
• Date: 2010
• Persistent ID: http://hdl.handle.net/10400.18/233
• Origin: Repositório Científico do Instituto Nacional de Saúde
• Subject(s): Doenças Cardio e Cérebro-vasculares
• Document Type: Article
• Language: English

Description

Multiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery.