Association of a genetic variant in the ALOX5AP with higher risk of ischemic st...

• Author(s): Domingues-Montanari, S. ; Fernández-Cadenas, I. ; Del Rio-Espinola, A. ; Corbeto, N. ; Krug, T. ; Manso, H. ; Gouveia, L. ; Sobral, J. ; Mendioroz, M. ; Fernández-Morales, J. ; Alvarez-Sabin, J. ; Ribó, M. ; Rubiera, M. ; Obach, V. ; Martí-Fàbregas, J. ; Freijo, M. ; Serena, J. ; Ferro, J.M. ; Vicente, A.M. ; Oliveira, S.A. ; Montaner, J.
• Date: 2010
• Persistent ID: http://hdl.handle.net/10400.18/172
• Origin: Repositório Científico do Instituto Nacional de Saúde
• Subject(s): ALOX5AP; Single nucleotide polymorphism; Meta-analysis; Stroke; Genetics; PDE4D; Doenças Cardio e Cérebro-vasculares
• Document Type: Article
• Language: English

Description

Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian population.