Giant cell glioblastoma: review of the literature and illustrated case

• Author(s): Valle-Folgueral, JM ; Mascarenhas, L ; Costa, JA ; Vieira, F ; Soares-Fernandes, J ; Beleza, P ; Alegria, C
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.23/145
• Origin: Repositório Científico do Hospital de Braga
• Subject(s): Neoplasias Cerebrais; Glioblastoma
• Document Type: Article
• Language: English

Description

Giant cell glioblastoma is an infrequent variety of glioblastoma (5% of the cases). It has deserved a separate category in the World Health Organization classification of grade IV tumors. The clinical, imaging, histological and immunohistochemical characteristics, and the genetic alterations are reviewed. Treatment and prognosis are discussed and updated. The case of a patient that survived 19 months and died of spinal leptomeningeal metastases is illustrated.