Practical aspects of the use of target controlled infusion with remifentanil in...

• Author(s): Ferreira, D. ; Nunes, C. ; Antunes, L. ; Lobo, F. ; Amorim, P.
• Date: 2006
• Persistent ID: http://hdl.handle.net/10400.16/817
• Origin: Repositório Científico do Centro Hospitalar do Porto
• Subject(s): Remifentanil; intubation; incision; extubation
• Document Type: Article
• Language: English

Description

Abstract Remifentanil has important side effects and it is not easy to know what remifentanil concentrations should be used during different endpoints of anaesthesia. We analyzed the remifentanil predicted effect-site concentrations (RemiCe) at different events during neurosurgical procedures and assessed if the concentrations used were clinically adequate. BIS and haemodynamic parameters were collected every 5 seconds. Predicted cerebral concentration of propofol (PropCe) and RemiCe were analyzed immediately prior to respective stimulus, and 30, 60 and 90 seconds after. RemiCe were 2.2 +/- 0.3, 6 +/- 2.6 and 2.2 +/- 0.9 ng ml(-1) at intubation, incision and extubation, respectively. PropCe observed in the same periods were 5 +/- 1, 2.6 +/- 0.9 and 1 +/- 0.3 microg ml(-1), also respectively. The remifentanil concentrations used in our patients were lower than reported concentrations, while being clinically adequate to minimize the haemodynamic response to stimulation.