Cutaneous necrobiotic xanthogranuloma (NXG)--successfully treated with low dose...

• Author(s): Machado, S. ; Alves, R. ; Lima, M. ; Leal, I. ; Massa, A.
• Date: 2001
• Persistent ID: http://hdl.handle.net/10400.16/798
• Origin: Repositório Científico do Centro Hospitalar do Porto
• Subject(s): necrobiotic xanthogranuloma; paraproteinemia
• Document Type: Article
• Language: English

Description

Eur J Dermatol. 2001 Sep-Oct;11(5):458-62. Cutaneous necrobiotic xanthogranuloma (NXG)--successfully treated with low dose chlorambucil. Machado S, Alves R, Lima M, Leal I, Massa A. SourceService of Dermatology, Hospital Geral Santo António, Rua D. Manuel II, Edifício ex: Cicap, 4099-001 Porto, Portugal. [e-mail] Abstract We report a case of necrobiotic xanthogranuloma in a 51 year-old white male patient presenting with a 6-year history of multiple indurated violaceous nodules and plaques involving the eyelids, trunk and extremities. He had an associated paraproteinemia (Ig G lambda), elevated sedimentation rate, cryoglobulinemia and hypocomplementemia. No extracutaneous involvement was detected. He was successfully treated with chlorambucil (2 mg/d for 7 months), leading to disappearance of all skin lesions.