Detalhes do Documento

Intraclonal diversity in a Sezary syndrome with a differential response to 2‐de...

Autor(es): GRANJO, E. cv logo 1 ; LIMA, M. cv logo 2 ; LOPES, J.M. cv logo 3 ; CUNHA, N. cv logo 4 ; TEIXEIRA, M. A. cv logo 5 ; SANTOS, F. cv logo 6 ; CANDEIAS, J. cv logo 7 ; RESENDE, C. cv logo 8 ; SANTOS, A.H. cv logo 9 ; BALANZATEGUI, A. cv logo 10 ; ORFAO, A. cv logo 11 ; MATUTES, E. cv logo 12

Data: 2002

Identificador Persistente: http://hdl.handle.net/10400.16/516

Origem: Repositório Científico do Centro Hospitalar do Porto


Descrição
Br J Haematol. 2002 Dec;119(3):629-33. Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations. Granjo E, Lima M, Lopes JM, Cunha N, Teixeira Mdos A, Santos F, Candeias J, Resende C, Santos AH, Balanzategui A, Orfão A, Matutes E. Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal. npp46740@mail.telpac.pt Abstract We report a case of Sezary syndrome with two abnormal CD4+ T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than a true biclonal disease. The patient achieved a transient response with 2-deoxycoformycin, with a selective decrease of the larger/hyperploid T-cell population; later on, an increased representation of this T-cell population was observed concomitantly with clinical relapse. PMID: 12437636 [PubMed - indexed for MEDLINE]
Tipo de Documento Artigo
Idioma Inglês
delicious logo  facebook logo  linkedin logo  twitter logo 
degois logo
mendeley logo

Documentos Relacionados



    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia