Inducibility of Atrial Fibrillation During Electrophysiologic Evaluation is Ass...

• Author(s): Oliveira, MM ; Nogueira da Silva, M ; Timóteo, AT ; Feliciano, J ; Sousa, L ; Santos, S ; Silva-Carvalho, L ; Cruz Ferreira, R
• Date: 2009
• Persistent ID: http://hdl.handle.net/10400.17/533
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Fibrilhação Auricular; Seio Coronário; Aurícula do Coração; Sistema de Condução Cardíaco; Septo Cardíaco; Modelos Logísticos; Análise Multivariada; Valor Preditivo dos Testes; Período Refractário Electrofisiológico; Índice de Gravidade da Doença
• Document Type: Article
• Language: English

Description

The impact of atrial dispersion of refractoriness (Disp_A) in the inducibility and maintenance of atrial fibrillation (AF) has not been fully resolved. AIM: To study the Disp_A and the vulnerability (A_Vuln) for the induction of self-limited (<60 s) and sustained episodes of AF. METHODS AND RESULTS: Forty-seven patients with paroxysmal AF (PAF): 29 patients without structural heart disease and 18 with hypertensive heart disease. Atrial effective refractory period (ERP) was assessed at five sites--right atrial appendage and low lateral right atrium, high interatrial septum, proximal and distal coronary sinus. We compared three groups: group A - AF not inducible (n=13); group B - AF inducible, self-limited (n=18); group C - AF inducible, sustained (n=16). Age, lone AF, hypertension, left atrial and left ventricular (LV) dimensions, LV systolic function, duration of AF history, atrial flutter/tachycardia, previous antiarrhythmics, and Disp_A were analysed with logistic regression to determine association with A_Vuln for AF inducibility. The ERP at different sites showed no differences among the groups. Group A had a lower Disp_A compared to group B (47+/-20 ms vs 82+/-65 ms; p=0.002), and when compared to group C (47+/-20 ms vs 80+/-55 ms; p=0.008). There was no significant difference in Disp_A between groups B and C. By means of multivariate regression analysis, the only predictor of A_Vuln was Disp_A (p=0.04). Conclusion: In patients with PAF, increased Disp_A represents an electrophysiological marker of A_Vuln. Inducibility of both self-limited and sustained episodes of AF is associated with similar values of Disp_A. These findings suggest that the maintenance of AF is influenced by additional factors.