Exacerbation of Recalcitrant Cutaneous Sarcoidosis with Adalimumab - a Paradoxi...

• Author(s): Santos, G ; Sousa, L ; João, A
• Date: 2013
• Persistent ID: http://hdl.handle.net/10400.17/1804
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): HSAC DER; Anti-Inflamatórios; Efeitos Adversos; Anticorpos Monoclonais Humanizados; Biópsia; Evolução da Doença; Sarcoidose; Doenças da Pele; Resultado de Tratamento; Factor de Necrose Tumoral Alfa
• Document Type: Article
• Language: English

Description

The paradoxical adverse effects of tumor necrosis factor-alpha (TNF-alpha) antagonists have been described frequently as a result of the widespread use of these drugs. Among the TNF-alpha blocking agents, few reports exist relating the use of adalimumab in cutaneous sarcoidosis, although all of them show good results. More recently, sarcoidosis onsets have been reported with various TNF-alpha inhibitors. The current case is, to our knowledge, the first to describe the exacerbation of cutaneous lesions of sarcoidosis treated with adalimumab.