Comparison of Methods and Co-Registration Maps of EEG and fMRI in Occipital Lob...

• Author(s): Forjaz Secca, M ; Leal, A ; Cabral, J ; Fernandes, H
• Date: 2007
• Persistent ID: http://hdl.handle.net/10400.17/1765
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): EEG; Imagem de Difusão por Ressonância Magnética; Epilepsia; HDE NEU PED
• Document Type: Conference Object
• Language: English

Description

Clinically childhood occipital lobe epilepsy (OLE) manifests itself with distinct syndromes. The traditional EEG recordings have not been able to overcome the difficulty in correlating the ictal clinical symptoms to the onset in particular areas of the occipital lobes. To understand these syndromes it is important to map with more precision the epileptogenic cortical regions in OLE. Experimentally, we studied three idiopathic childhood OLE patients with EEG source analysis and with the simultaneous acquisition of EEG and fMRI, to map the BOLD effect associated with EEG spikes. The spatial overlap between the EEG and BOLD results was not very good, but the fMRI suggested localizations more consistent with the ictal clinical manifestations of each type of epileptic syndrome. Since our first results show that by associating the BOLD effect with interictal spikes the epileptogenic areas are mapped to localizations different from those calculated from EEG sources and that by using different EEG/fMRI processing methods our results differ to some extent, it is very important to compare the different methods of processing the localization of activation and develop a good methodology for obtaining co-registration maps of high resolution EEG with BOLD localizations.