Acquired-Transient Factor X Deficiency in a Teenager with Extensive Burns

• Author(s): Mascarenhas, A ; Eusébio, M ; Freitas, O ; Almeida, T
• Date: 2011
• Persistent ID: http://hdl.handle.net/10400.17/1555
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Factor X; Queimaduras; Adolescente; HDE PED; HDE HEM PED
• Document Type: Article
• Language: English

Description

Acquired factor X deficiency is an extremely rare situation. It has shown to be associated with systemic amyloidosis, respiratory mycoplasma infection, factor X inhibitors, antiphospholipid antibodies, vitamin K defi ciency/liver disease as well as the use of certain medications (meropenem, valproic acid). The pathogenesis and transient nature of this deficit remain poorly understood. The authors describe the case of a teenager hospitalised for extensive burns that developed active bleeding after removal of central venous catheter. He was diagnosed with transient factor X deficiency. Normalisation of coagulation status and factor X levels occurred spontaneously 10 days after the bleeding episode.