Modeling in-Hospital Patient Survival During the First 28 Days After Intensive ...

• Autor(es): Moreno, R ; Metnitz, P ; Metnitz, B ; Bauer, P ; Afonso de Carvalho, S ; Hoechtl, A ; SAPS 3 Investigators
• Data: 2008
• Identificador Persistente: http://hdl.handle.net/10400.17/1429
• Origem: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Assunto(s): Ensaios Clínicos Como Assunto; Estado Terminal; Mortalidade Hospitalar; Unidades de Cuidados Intensivos; Modelos Estatísticos; Prognóstico; Avaliação de Risco; Índice de Gravidade da Doença; Factores de Tempo
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

OBJECTIVE: The objective of the study was to develop a model for estimating patient 28-day in-hospital mortality using 2 different statistical approaches. DESIGN: The study was designed to develop an outcome prediction model for 28-day in-hospital mortality using (a) logistic regression with random effects and (b) a multilevel Cox proportional hazards model. SETTING: The study involved 305 intensive care units (ICUs) from the basic Simplified Acute Physiology Score (SAPS) 3 cohort. PATIENTS AND PARTICIPANTS: Patients (n = 17138) were from the SAPS 3 database with follow-up data pertaining to the first 28 days in hospital after ICU admission. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: The database was divided randomly into 5 roughly equal-sized parts (at the ICU level). It was thus possible to run the model-building procedure 5 times, each time taking four fifths of the sample as a development set and the remaining fifth as the validation set. At 28 days after ICU admission, 19.98% of the patients were still in the hospital. Because of the different sampling space and outcome variables, both models presented a better fit in this sample than did the SAPS 3 admission score calibrated to vital status at hospital discharge, both on the general population and in major subgroups. CONCLUSIONS: Both statistical methods can be used to model the 28-day in-hospital mortality better than the SAPS 3 admission model. However, because the logistic regression approach is specifically designed to forecast 28-day mortality, and given the high uncertainty associated with the assumption of the proportionality of risks in the Cox model, the logistic regression approach proved to be superior.