Pustulose Generalizada Exantemática Aguda Associada ao Diltiazem

• Author(s): Serrão, V ; Caldas Lopes, L ; Campos Lopes, JM ; Lobo, L ; Ferreira, A
• Date: 2008
• Persistent ID: http://hdl.handle.net/10400.17/141
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Adulto; Erupções por Medicamento; Efeitos Adversos; Diltiazem; Doenças da Pele; Exantema
• Document Type: Article
• Language: Portuguese

Description

Acute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent.