Borderline CD30+ Cutaneous Lymphoproliferative Disorder: Report of a Case with ...

• Autor(es): Ponte, P ; Serrão, V ; Viana, I ; Vale, E ; João, A ; Cerroni, L
• Data: 2011
• Identificador Persistente: http://hdl.handle.net/10400.17/1006
• Origem: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Assunto(s): Anti-Inflamatórios; Antigénio CD30; Claritromicina; Linfoma Cutâneo de Células T; Neoplasias da Pele; Marcadores Biológicos de Tumor
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

CD30+ cutaneous lymphoproliferative disorders (CLPDs) are usually characterized by a benign clinical course. The prognostic value of cytotoxic markers in these lymphomas has not been evaluated in large series. We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may have hastened the remission process.