Autor(es):
Paula Vaz 
; João Sampaio Fernandes ; A.C. Braga ; Maria João Ponces ; António Felino
Data: 2012
Identificador Persistente: http://hdl.handle.net/10216/68021
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): Ciências da Saúde
Descrição
Aim
The aim of this study was to analyse the possible association between no success of dental implants and two polymorphisms, IL1A (-889) and IL1B (+3953), in a Caucasian Portuguese population, and a possible relationship with other potential risk variables associated with a peri-implant disease.
Material and Methods
155 unrelated Caucasian individuals, were divided into 2 groups: 100 with successful dental implant rehabilitations and 55 with unsuccessful ones. To identify the polymorphisms, in positions -889 of IL1A gene and +3953 of IL1B gene, was performed an oral mucosa scraping of the patients and the DNA obtained from epithelial cells. The data were analysed in the SPSS Statistics 17.0® and the statistic analysis included the independence test of the chi-square, the exact test of Fisher and techniques of analysis of binary logistic regression.
Results
The estimated prevalence of polymorphisms of IL1A and IL1B gene, determined by the TGP (CGC Genetics, Portugal) results, in the Caucasian Portuguese population was of 33.5%.
Success of rehabilitation with dental implants was more associated to a negative TGP result, whereas failure was found to be related to a positive result.
Tobacco and alcohol consumption showed no statistically significant association with success or no success of the dental implants.
Conclusion
The success of the dental implants was more associated with the presence of the allele 2 of the IL1A gene and the allele 2 of the IL1B gene.
Tobacco and alcohol consumption showed no association with success or no success of the rehabilitation with dental implants.
