Author(s):
Pegiadou, S. 
; Guthrie, J. T. ; Gill, M. H.
Date: 1998
Persistent ID: http://hdl.handle.net/10316/8248
Origin: Estudo Geral - Universidade de Coimbra
Document details
The synthesis and characterization of new polymerizable pyrimidines: Immobiliza...
Description
Polymerizable quaternary allyl-pyrimidinium salts, that is, 1-allyl-4- amino-5-phenyl-pyrimidine (IV), 1-allyl-4-acetamido-5-phenyl-pyrimidine (V), 1-allyl-5-hydroxymethylamino-5-phenyl-pyrimidine (VI), and 1-allyl-pyrimidine (VIII) bromides, as well as 4-acrylamido-5-phenyl-pyrimidines II` and IV`, were synthesized and characterized. Three of the activated pyrimidine derivatives, the two acrylamido and one allyl pyrimidine, were immobilized onto (Agar-g-co-HEMA)-X-TMPTA via graft copolymerization. Each copolymer system, based on 2-hydroxyethyl methacrylate (HEMA) grafted onto Agar followed by crosslinking with trimethyllopropane triacrylate (TMPTA), was prepared by radiation-induced copolymerization carried out in the simultaneous mode. The release properties of the immobilized pyrimidines were assessed in various aqueous media over a period of approximately 22 days. © 1998 John Wiley & Sons, Inc. J. Appl. Polym. Sci. 70: 211-218, 1998 http://dx.doi.org/10.1002/(SICI)1097-4628(19981010)70:2<211::AID-APP1>3.0.CO;2-X
Polymerizable quaternary allyl-pyrimidinium salts, that is, 1-allyl-4- amino-5-phenyl-pyrimidine (IV), 1-allyl-4-acetamido-5-phenyl-pyrimidine (V), 1-allyl-5-hydroxymethylamino-5-phenyl-pyrimidine (VI), and 1-allyl-pyrimidine (VIII) bromides, as well as 4-acrylamido-5-phenyl-pyrimidines II` and IV`, were synthesized and characterized. Three of the activated pyrimidine derivatives, the two acrylamido and one allyl pyrimidine, were immobilized onto (Agar-g-co-HEMA)-X-TMPTA via graft copolymerization. Each copolymer system, based on 2-hydroxyethyl methacrylate (HEMA) grafted onto Agar followed by crosslinking with trimethyllopropane triacrylate (TMPTA), was prepared by radiation-induced copolymerization carried out in the simultaneous mode. The release properties of the immobilized pyrimidines were assessed in various aqueous media over a period of approximately 22 days. © 1998 John Wiley & Sons, Inc. J. Appl. Polym. Sci. 70: 211-218, 1998 http://dx.doi.org/10.1002/(SICI)1097-4628(19981010)70:2<211::AID-APP1>3.0.CO;2-X
Document Type
Article
Language English
Language English
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