Author(s):
Ferreira, P. 
; Coelho, J. F. J. ; Pereira, R. ; Silva, António F. M. ; Gil, M. H.
Date: 2007
Persistent ID: http://hdl.handle.net/10316/8197
Origin: Estudo Geral - Universidade de Coimbra
Document details
Synthesis and characterization of a poly(ethylene glycol) prepolymer to be appl...
Description
Surgical adhesives can be applied to wound closure and to covering and protecting surface wounds. Depending on their degradability, they can then slough off or can be reabsorbed by the organism when the wound initiates the healing process. In this work, we intended to develop a new urethane-based bioadhesive that could accomplish these purposes. Urethanes are considered to be promising candidates as adhesives because of the possibility of their synthesis as prepolymers and therefore their reaction with amino groups present in the biological molecules. Some urethanes were obtained by the reaction of poly(ethylene glycol) with isophorone diisocyanate. The characterization of the various materials was accomplished with different techniques: attenuated total reflection/Fourier transform infrared, swelling-capacity determination, the evaluation of the moisture-curing kinetics, a reaction with aminated substrates (as a simulation of the living tissues), and the determination of the surface energy by contact-angle measurements. The study of the thermal properties of the urethanes was performed by dynamical mechanical thermal analysis, differential scanning calorimetry, and thermogravimetric analysis. The hemocompatibility of the urethane was also evaluated by thrombosis and hemolysis tests. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007 http://dx.doi.org/10.1002/app.26206
Surgical adhesives can be applied to wound closure and to covering and protecting surface wounds. Depending on their degradability, they can then slough off or can be reabsorbed by the organism when the wound initiates the healing process. In this work, we intended to develop a new urethane-based bioadhesive that could accomplish these purposes. Urethanes are considered to be promising candidates as adhesives because of the possibility of their synthesis as prepolymers and therefore their reaction with amino groups present in the biological molecules. Some urethanes were obtained by the reaction of poly(ethylene glycol) with isophorone diisocyanate. The characterization of the various materials was accomplished with different techniques: attenuated total reflection/Fourier transform infrared, swelling-capacity determination, the evaluation of the moisture-curing kinetics, a reaction with aminated substrates (as a simulation of the living tissues), and the determination of the surface energy by contact-angle measurements. The study of the thermal properties of the urethanes was performed by dynamical mechanical thermal analysis, differential scanning calorimetry, and thermogravimetric analysis. The hemocompatibility of the urethane was also evaluated by thrombosis and hemolysis tests. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007 http://dx.doi.org/10.1002/app.26206
Document Type
Article
Language English
Language English
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||