Autor(es):
Manco, Licínio 
; Machado, Patrícia ; Lopes, Dinora ; Nogueira, Fátima ; Rosário, Virgílio E. Do ; Alonso, Pedro L. ; Varandas, Luís ; Trovoada, Maria De Jesus ; Amorim, António ; Arez, Ana Paula
Data: 2009
Identificador Persistente: http://hdl.handle.net/10316/8070
Origem: Estudo Geral - Universidade de Coimbra
Descrição
Population samples from Angola, Mozambique, and S. Tomé e Príncipe were screened for the TPI gene promoter variants -5ArarrG, -8GrarrA and -24TrarrG. Three haplotypes were identified in the three populations: the haplotype -5A-8G-24T (average frequency 65.3%) and two less common haplotypes -5G-8G-24T (average frequency 24.7%) and -5G-8A-24T (average frequency 10.0%). A population sample from Central Portugal showed the haplotype -5A-8G-24T in 139 chromosomes and one subject heterozygous for haplotype -5G-8A-24G. The exact test of sample differentiation among three groups of malaria-infected individuals classified according to the severity of the disease showed no significant differences. We confirmed TPI gene diversity in sub-Saharan Africa, but we could not detect any association between TPI promoter variation and a malarial protective effect. Larger scale epidemiological studies are thus required to clarify this putative mechanism of natural host defense against this worldwide public health problem http://dx.doi.org/10.1002/ajhb.20819
