Autor(es):
Figueiras, Ana 
; Ribeiro, Laura ; Vieira, M. ; Veiga, Francisco
Data: 2007
Identificador Persistente: http://hdl.handle.net/10316/7956
Origem: Estudo Geral - Universidade de Coimbra
Detalhes do Documento
Preparation and physicochemical characterization of omeprazole:methyl-beta-cycl...
Descrição
Abstract In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-ß-cyclodextrin (MßCD), an amorphous, methylated derivative of the natural ß-cyclodextrin (ßCD), as a tool to form an inclusion complex with omeprazole (OME), a poorly water soluble drug. Solid binary systems between OME and MßCD were prepared experimentally in a stoichiometry 1:1 by different techniques (physical mixing, kneading, spray-drying and freeze-drying). Afterward these products were characterized by Fourier transformation-infrared spectroscopy (FTIR); X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results obtained suggest that spray-drying and freeze-drying methods yield a higher degree of amorphous entities suggesting the formation of inclusion complexes between OME and MßCD. http://dx.doi.org/10.1007/s10847-006-9200-4
Abstract In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-ß-cyclodextrin (MßCD), an amorphous, methylated derivative of the natural ß-cyclodextrin (ßCD), as a tool to form an inclusion complex with omeprazole (OME), a poorly water soluble drug. Solid binary systems between OME and MßCD were prepared experimentally in a stoichiometry 1:1 by different techniques (physical mixing, kneading, spray-drying and freeze-drying). Afterward these products were characterized by Fourier transformation-infrared spectroscopy (FTIR); X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results obtained suggest that spray-drying and freeze-drying methods yield a higher degree of amorphous entities suggesting the formation of inclusion complexes between OME and MßCD. http://dx.doi.org/10.1007/s10847-006-9200-4
Tipo de Documento
Artigo
Idioma Inglês
Idioma Inglês
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