Allylic and benzylic oxidation reactions with sodium chlorite

• Author(s): Silvestre, Samuel M. ; Salvador, Jorge A. R.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10316/5861
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Sodium chlorite; Allylic oxidation; Benzylic oxidation; Transition-metal free
• Document Type: Article
• Language: English

Description

Various allylic and benzylic substrates were selectively oxidized to the corresponding enones in good yields using sodium chlorite, either in combination with tert-butyl hydroperoxide in stoichiometric conditions, or associated with N-hydroxyphthalimide as catalyst. These oxidation reactions were effectively and economically performed under mild, transition-metal free conditions and therefore the dual challenge of cost effectiveness and benign nature of the processes was met with. http://www.sciencedirect.com/science/article/B6THR-4MT5JX3-5/1/64e51e9b1aae448b3f47f8c2efad85af