Regioselective enzymatic acylation of vicinal diols of steroids

• Autor(es): Silva, M. Manuel Cruz ; Riva, Sergio ; Melo, M. Luísa Sá e
• Data: 2005
• Identificador Persistente: http://hdl.handle.net/10316/5756
• Origem: Estudo Geral - Universidade de Coimbra
• Assunto(s): Lipases; Steroids; Regioselectivity; Enzymatic esterification
• Tipo de Documento: Artigo
• Idioma: Inglês

Descrição

Monoacylated derivatives of a complete set of 2,3- and 3,4-vicinal diols of steroids were prepared by regioselective lipase-catalysed transesterification reactions. The enzymes displayed different selectivities towards the vicinal diols depending on the configuration of the hydroxyl groups. http://www.sciencedirect.com/science/article/B6THR-4FGX84H-2/1/c23744db4c590d02acf7c82018be5720