Synthesis of novel tricyclic isoindole derivatives

• Author(s): Melo, Teresa M. V. D. Pinho e ; Santos, Catarina I. A. ; Gonsalves, António M. d'A. Rocha ; Paixão, José A. ; Beja, Ana M. ; Silva, Manuela Ramos
• Date: 2003
• Persistent ID: http://hdl.handle.net/10316/5154
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): diastereoselectivity; thiazolo[2,3-a]isoindoles; 3-methylene-2,5-oxazolo[2,3-a]isoindoles
• Document Type: Article
• Language: English

Description

Novel 3-methylene-2,5-dioxo-3H,9bH-oxazolo[2,3-a]isoindoles were prepared from the thermolysis of (3R,9bS)-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole-3-carboxylic acids in acetic anhydride. The structure of 3-methylene-2,5-dioxo-3H,9bH-oxazolo[2,3-a]isoindole 6a was determined by X-ray crystallography. http://www.sciencedirect.com/science/article/B6THS-49PXCD9-X/1/45bd0f04f44115a1e7b644d727569da1