1,3-Dipolar cycloaddition of azomethine ylides generated from aziridines in sup...

• Author(s): Gomes, Paulo J. S. ; Nunes, Cláudio M. ; Pais, Alberto A. C. C. ; Melo, Teresa M. V. D. Pinho e ; Arnaut, Luis G.
• Date: 2006
• Persistent ID: http://hdl.handle.net/10316/5078
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Supercritical carbon dioxide; 1,3-Dipolar cycloaddition; Azomethine ylides; Aziridines
• Document Type: Article
• Language: English

Description

The 1,3-dipolar cycloaddition of azomethine ylides with DMAD in supercritical carbon dioxide is reported. The photolysis reaction conditions were optimized with a suitable adjustment of pressure, temperature, irradiation time and co-solvent concentration leading to a more efficient reaction than in neat acetonitrile. Similar results were observed using thermal reaction conditions. Supercritical carbon dioxide with a minute co-solvent addition is shown to be a very efficient medium for promoting this type of cycloadditions. http://www.sciencedirect.com/science/article/B6THS-4K7FJ88-D/1/e5b9b60b4e9f3055fb5a425dfc759395