Halogen atom effect on photophysical and photodynamic characteristics of deriva...

• Author(s): Serra, A. C. ; Pineiro, M. ; Gonsalves, A. M. d'A. Rocha ; Abrantes, M. ; Laranjo, M. ; Santos, A. C. ; Botelho, M. F.
• Date: 2008
• Persistent ID: http://hdl.handle.net/10316/5000
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): Halogenated porphyrins; Photodynamic therapy; Heavy atom effect
• Document Type: Article
• Language: English

Description

Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells. http://www.sciencedirect.com/science/article/B6TH0-4SCKRV7-2/1/f341bf72f1ad4338d46c1c71eadc64e3