Author(s):
Massano, João 
; Regateiro, Frederico S. ; Januário, Gustavo ; Ferreira, Artur
Date: 2006
Persistent ID: http://hdl.handle.net/10316/4741
Origin: Estudo Geral - Universidade de Coimbra
Document details
Oral squamous cell carcinoma: Review of prognostic and predictive factors
Description
Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome. In this review article, the authors approach the factors that may exert influence on the prognosis and eventually guide the selection of patients for more aggressive therapies. Published scientific data was collected, selected, and grouped into 3 main clusters: patient-, tumor-, and treatment-related factors. Well established aspects are discussed, but also those less common or with only supposed usefulness. Disease staging, extracapsular dissemination, resection margin free of disease, and tumor thickness are factors with high influence on the prognosis. There has been an increasing interest in the study of tumor molecular factors, and some have been strongly correlated with the outcome, showing promising pathways for the future development of more effective prognosis systems and anticancer therapies. http://www.sciencedirect.com/science/article/B6WP1-4J0WTPM-3/1/71bafa4352dd7cfb29bd0c9c32f6991d
Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome. In this review article, the authors approach the factors that may exert influence on the prognosis and eventually guide the selection of patients for more aggressive therapies. Published scientific data was collected, selected, and grouped into 3 main clusters: patient-, tumor-, and treatment-related factors. Well established aspects are discussed, but also those less common or with only supposed usefulness. Disease staging, extracapsular dissemination, resection margin free of disease, and tumor thickness are factors with high influence on the prognosis. There has been an increasing interest in the study of tumor molecular factors, and some have been strongly correlated with the outcome, showing promising pathways for the future development of more effective prognosis systems and anticancer therapies. http://www.sciencedirect.com/science/article/B6WP1-4J0WTPM-3/1/71bafa4352dd7cfb29bd0c9c32f6991d
Document Type
Article
Language English
Language English
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