Author(s):
Baudot, Anne 
; Cacela, Constança ; Duarte, Maria Leonor ; Fausto, Rui
Date: 2002
Persistent ID: http://hdl.handle.net/10316/17773
Origin: Estudo Geral - Universidade de Coimbra
Document details
Thermal study of simple amino-alcohol solutions
Description
Widely regarded as the most promising approach to long-term cryopreservation of organs for transplantation, vitrification is a process where liquid is transformed into a disordered solid state free from crystals, known as the amorphous state. The vitreous state is obtained by rapid cooling to cryogenic temperatures in the presence of antifreeze substances called cryoprotectants, such as polyalcohols, which are known to be very good vitrification agents. This work reports on the thermal properties of a new class of compounds, the amino-alcohols, studied for its similarity to the structure of the equivalent polyalcohols. We studied by differential scanning calorimetry the glass-forming tendency and stability of the amorphous state for de-ionized water solutions containing 2-amino-1-ethanol and 3-amino-1-propanol at the concentrations of 35%, 40%, 43%, and 45% (w/w). A comparison is made with previous results obtained by Mehl [Cryobiology 27 (1990) 687–688] on the same compounds under different experimental conditions. The results are also compared with those obtained by Boutron [Cryobiology 30 (1993) 87–97] for the corresponding dialcohols. A further comparison is made with a few results obtained for the 1-amino-2-propanol and the 2-amino-1-propanol tested under the same conditions
Widely regarded as the most promising approach to long-term cryopreservation of organs for transplantation, vitrification is a process where liquid is transformed into a disordered solid state free from crystals, known as the amorphous state. The vitreous state is obtained by rapid cooling to cryogenic temperatures in the presence of antifreeze substances called cryoprotectants, such as polyalcohols, which are known to be very good vitrification agents. This work reports on the thermal properties of a new class of compounds, the amino-alcohols, studied for its similarity to the structure of the equivalent polyalcohols. We studied by differential scanning calorimetry the glass-forming tendency and stability of the amorphous state for de-ionized water solutions containing 2-amino-1-ethanol and 3-amino-1-propanol at the concentrations of 35%, 40%, 43%, and 45% (w/w). A comparison is made with previous results obtained by Mehl [Cryobiology 27 (1990) 687–688] on the same compounds under different experimental conditions. The results are also compared with those obtained by Boutron [Cryobiology 30 (1993) 87–97] for the corresponding dialcohols. A further comparison is made with a few results obtained for the 1-amino-2-propanol and the 2-amino-1-propanol tested under the same conditions
Document Type
Article
Language English
Language English
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