Detalhes do Documento

Toxicological and pharmacological evaluation of the essential oil and aqueous e...

Autor(es): Arantes, Silvia cv logo 1 ; Candeias, M. Fátima cv logo 2 ; Pereira, Marizia cv logo 3 ; Lopes, Orlando cv logo 4 ; Lima, Mónica cv logo 5 ; Martins, M. Rosário cv logo 6

Data: 2013

Identificador Persistente: http://hdl.handle.net/10174/9788

Origem: Repositório Científico da Universidade de Évora

Assunto(s): Lavandula stoechas ssp. luisieri; essential oil; toxicological evaluation; farmacological actvity


Descrição
Lavenders belong to the family Labiatae and represent some of the most popular medicinal plants extensively used in aromatherapy. In this study, we selected Lavandula stoechas L. subsp. luisieri (Rozeira) Rozeira, endemic of Portugal, collected in Évora (Alentejo). The aim of this study was to evaluate the acute toxicity and the analgesic and anti-inflammatory activities of the essential oil and aqueous extract from leaves of L. luisieri. The essential oil was obtained by hydrodistillation in Clevenger type apparatus and the resulting hydrolate was lyophilized. Chemical composition of essential oil was evaluated by GC/FID and extract was characterized by phytochemical tests and total phenolics and flavonoids quantification. Acute toxicity was evaluated in vitro in brine shrimp (LC50) and in vivo in Swiss mice, by pharmacological screening, determination of LD50, according to Up-and-Down OECD Procedure and liver and kidney histopathological study. Pharmacological properties, namely, analgesic and anti- inflammatory activities were evaluated in rats.
Tipo de Documento Artigo
Idioma Inglês
Editor(es) Correia, A. C. M.; Coimbra, M. A.
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