Autor(es):
Areal, A 
; Moreira, M ; Nunes, S ; Faustino, MA ; Cardoso, L ; Sá, C
Data: 2008
Origem: Repositório Comum
Assunto(s): Complicações Infecciosas na Gravidez; Infecções Estreptocócicas; Streptococcus agalactiae
Descrição
Aim and Objective: During the past three decades, group B Streptococcus (GBS) neonatal infection has
been the subject of little research. The aim of this study was to evaluate the association between maternal
risk factors, as established by the Center for Disease Control and Prevention (CDC), and maternal
colonization. We also analysed the association between risk factors present in newborns and early-onset
GBS disease.
Study design: Cross-sectional study.
Population: All pregnant women admitted for delivery in our institution and their newborns,
between 1st February and 31st July 2005.
Methods: Maternal and neonatal characteristics were collected from hospital clinical data, including
information on risk factors established by the CDC. Descriptive statistics was used to characterize
the study sample. Qui-square and Mantel-haenszel tests were applied to compare proportions and to
measure the strength of associations, respectively, setting significance at p < 0,05.
Results: In this sample only 47% of women were screened for GBS colonization in suitable time and
34,9% of these women were colonized. The incidence of early neonatal infection by SGB was 9/1000
neonates. Significant associations between GBS maternal colonization ant the following parameters
were observed: maternal age [p=0,012; OR=1,659 (IC a 95%, 1,218-2,260)], gestational age at
labour [p=0,001; OR= 2,621 (IC a 95%, 1,641- 4,188)], and urinary GBS infection during pregnancy
(p<0,001). Maternal colonization occurred in women without CDC defined risk factors. Early neonatal
infection by SGB was strongly associated with unscreened women (p=0,014).
Conclusion: In this study, maternal GBS colonization occurred in the absence of CDC defined risk
factors and varied according to maternal age and gestational week. Neonatal GBS infection was more frequent in unscreened women.
