Development of ketoprofen delivery systems based on aqueous polyurethane disper...

• Author(s): Leite, E. ; Fernandes, I. ; Ayres, E. ; Barreiro, M.F. ; Silva-Cunha, A.
• Date: 2013
• Persistent ID: http://hdl.handle.net/10198/9430
• Origin: Biblioteca Digital do IPB
• Subject(s): Ketoprofen; Aqueous polyurethane dispersions; Controlled release
• Document Type: Conference Object
• Language: English

Description

Ketoprofen (2-(3-benzoylphenyl) propionic acid) is a non-steroidal anti-inflammatory drug (NSAID) used to treat a wide range of acute and chronic inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Its prolonged oral administration is associated with several gastrointestinal reactions such as irritation and ulceration. In this context, ketoprofen is a good candidate for controlled release administration systems. This work aims to test the suitability of using aqueous polyurethane dispersions (PUDs) as the base vehicle for producing ketoprofen controlled release systems. Polyester (polycaprolactone, PCL) and polyether (polypropylene glycol, PPG) based PUDs have been synthesized by using a modified pre-polymer method. Two chain extenders have been assayed (ethylenediamina (EDA) and hydrazine monohydrate (HYD)).