Synthesis of Novel 1-Aryl-9H-xanthen-9-ones

• Author(s): Esteves, Cátia ; Santos, Clementina M.M. ; Brito, Cristela ; Silva, Artur ; Cavaleiro, José
• Date: 2011
• Persistent ID: http://hdl.handle.net/10198/6239
• Origin: Biblioteca Digital do IPB
• Subject(s): 1-arylxanthones; 2-methylchromone; Aldol condensation; Electrocyclization; Oxidation
• Document Type: Article
• Language: English

Description

A novel route for the synthesis of 1-aryl-9H-xanthen-9-ones is reported. This methodology involves the condensation of 2-methylchromone with cinammaldehydes leading to (E,E)-2-(4-arylbuta-1,3-dien-1-yl)-4H-chromen-4-ones. The final step was the electrocyclization and oxidation reactions of the latter compounds, in an one-pot synthesis, giving the desired 1-aryl-9H-xanthen-9-ones.