Increased polyclonal immunoglobulin reactivity toward human and bacterial prote...

• Author(s): Fesel, C. ; Goulart, L.F. ; Neto, A.S. ; Coelho, A. ; Fontes, C.J.F. ; Braga, E.M. ; Vaz, N.M.
• Date: 2005
• Persistent ID: http://hdl.handle.net/10400.7/216
• Origin: ARCA - Access to Research and Communication Annals
• Subject(s): Immunity, Innate/immunology; Immunoglobulin G/blood; Immunoglobulin G/immunology; Malaria, Falciparum/epidemiology; Malaria, Falciparum/immunology; Malaria, Vivax/epidemiology; Malaria, Vivax/immunology; Escherichia coli Proteins/immunology
• Document Type: Article
• Language: English

Description

The observed difference in polyclonal antibody production seems related to intrinsic activation states of infected individuals, rather than to parasite-antigen specific immune responses. However, it appears influenced by preceding stimuli. This supports the idea that acquired clinical immunity may not exclusively depend on antigen-specific responses, but also on the individual polyclonal reaction.